In an average healthy person, approximately 45 percent of the blood volume is cells, among them red cells (the majority), white cells, and platelets. A clear, yellowish fluid called plasma makes up the rest of blood. Plasma, 95 percent of which is water, also contains nutrients such as glucose, fats, proteins, and the amino acids needed for protein synthesis, vitamins, and minerals. The level of salt in plasma is about equal to that of sea water. The test tube on the right has been centrifuged to separate plasma and packed cells by density.

 The heart, blood, and blood vessels are the three structural elements that make up the circulatory system. The heart is the engine of the circulatory system. It is divided into four chambers: the right atrium, the right ventricle, the left atrium, and the left ventricle. The walls of these chambers are made of a special muscle called myocardium, which contracts continuously and rhythmically to pump blood. The pumping action of the heart occurs in two stages for each heart beat: diastole, when the heart is at rest; and systole, when the heart contracts to pump deoxygenated blood toward the lungs and oxygenated blood to the body. During each heartbeat, typically about 60 to 90 ml (about 2 to 3 oz) of blood are pumped out of the heart. If the heart stops pumping, death usually occurs within four to five minutes.

 Three types of blood vessels form a complex network of tubes throughout the body. Arteries carry blood away from the heart, and veins carry it toward the heart. Capillaries are the tiny links between the arteries and the veins where oxygen and nutrients diffuse to body tissues. The inner layer of blood vessels is lined with endothelial cells that create a smooth passage for the transit of blood. This inner layer is surrounded by connective tissue and smooth muscle that enable the blood vessel to expand or contract. Blood vessels expand during exercise to meet the increased demand for blood and to cool the body. Blood vessels contract after an injury to reduce bleeding and also to conserve body heat.

 Arteries have thicker walls than veins to withstand the pressure of blood being pumped from the heart. Blood in the veins is at a lower pressure, so veins have one-way valves to prevent blood from flowing backwards away from the heart. Capillaries, the smallest of blood vessels, are only visible by microscope—ten capillaries lying side by side are barely as thick as a human hair. If all the arteries, veins, and capillaries in the human body were placed end to end, the total length would equal more than 100,000 km (more than 60,000 mi)—they could stretch around the earth nearly two and a half times.

 The arteries, veins, and capillaries are divided into two systems of circulation: systemic and pulmonary. The systemic circulation carries oxygenated blood from the heart to all the tissues in the body except the lungs and returns deoxygenated blood carrying waste products, such as carbon dioxide, back to the heart. The pulmonary circulation carries this spent blood from the heart to the lungs. In the lungs, the blood releases its carbon dioxide and absorbs oxygen. The oxygenated blood then returns to the heart before transferring to the systemic circulation.